Reactome: A Curated Pathway Database

Gap junction assembly (R-HSA-190861) [Homo sapiens]


The assembly of gap junctions involves (1) synthesis of connexin polypeptides at endoplasmic reticulum membranes, (2) oligomerization into homomeric- and heteromeric gap junction connexons (hemi-channels), (3) passage through the Golgi stacks, (4) intracellular storage within Trans Golgi membranes, (5) trafficking along microtubules, (6) insertion of connexons into the plasma membrane, (7) lateral diffusion of connexons in the plasma membrane, (8) aggregation of individual gap junction channels into plaques, and (9) stabilization of peripheral microtubule plus-ends by binding to Cx43-based gap junctions (see Segretain and Falk, 2004.)

Additional Information
Compartment cytosol
GO Biological Process gap junction assembly (0016264)
Literature References
pubMedId Title Journal Year
15033576 Regulation of connexin biosynthesis, assembly, gap junction formation, and removal Biochim Biophys Acta 2004
8665925 Connections with connexins: the molecular basis of direct intercellular signaling Eur J Biochem 1996