Reactome: A Curated Pathway Database
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Transport of connexons to the plasma membrane

Stable Identifier
R-HSA-190872
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Following connexon oligomerization, the hemichannels must be transported to the plasma membrane. This has been shown to occur in transport vesicles called "cargo containers". Most of post-Golgi cargo containers have a diameter of of 50- 200 nm (Lauf et al., 2002). Recently direct transport of connexins to GJ assembly sides has been described (Shaw et al., 2007). Besides microtuble-dependent trafficking, a microtubule-independent delivery pathway may exist as concluded from studies using the secretory transport inhibitor, Brefeldin A (Musil and Goodenough 1993; De Sousa et al. 1993; Laird et al. 1995).

Literature References
Participants
Participant Of
Orthologous Events