Following connexon oligomerization, the hemichannels must be transported to the plasma membrane. This has been shown to occur in transport vesicles called "cargo containers". Most of post-Golgi cargo containers have a diameter of of 50- 200 nm (Lauf et al., 2002). Recently direct transport of connexins to GJ assembly sides has been described (Shaw et al., 2007). Besides microtuble-dependent trafficking, a microtubule-independent delivery pathway may exist as concluded from studies using the secretory transport inhibitor, Brefeldin A (Musil and Goodenough 1993; De Sousa et al. 1993; Laird et al. 1995).
|8404537||Connexin trafficking and the control of gap junction assembly in mouse preimplantation embryos||Development||1993|
|12149451||Dynamic trafficking and delivery of connexons to the plasma membrane and accretion to gap junctions in living cells||Proc Natl Acad Sci U S A||2002|
|8522583||Gap junction turnover, intracellular trafficking, and phosphorylation of connexin43 in brefeldin A-treated rat mammary tumor cells||J Cell Biol||1995|
|17289573||Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions||Cell||2007|
|7691412||Multisubunit assembly of an integral plasma membrane channel protein, gap junction connexin43, occurs after exit from the ER||Cell||1993|