Reactome: A Curated Pathway Database
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Gap junction degradation

Stable Identifier
R-HSA-190873
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The half-life of Cx is very short (1 to 5h) compared to other junctional proteins (Laird et al., 1995 ; Fallon and Goudenough, 1981). Connexins are targeted for degradation by the proteasome and the lysosome. Degradation appears to involve the phosphorylation of Connexins as well as their interactions with other proteins (Piehl et al., 2007).

Literature References
Participants
Participant Of
Orthologous Events