Reactome: A Curated Pathway Database

Mature NOTCH heterodimer traffics to the plasma membrane (R-HSA-1912382) [Homo sapiens]

Black Box Event
Summation

Mature NOTCH translocates from the Golgi to plasma membrane. In Caenorhabditis elegans, a Golgi membrane protein sel-9, a homolog of mammalian TMED2, acts as a quality controller and prevents misfolded lin-12, a NOTCH homolog, to reach the cell surface.

Additional Information
Compartment cytosol
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Regulation type Name
NegativeRegulation