Mature NOTCH heterodimer traffics to the plasma membrane

Stable Identifier
R-HSA-1912382
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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Summation

Mature NOTCH translocates from the Golgi to plasma membrane. In Caenorhabditis elegans, a Golgi membrane protein sel-9, a homolog of mammalian TMED2, acts as a quality controller and prevents misfolded lin-12, a NOTCH homolog, to reach the cell surface.

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Orthologous Events