Reactome: A Curated Pathway Database

NOTCH1 mRNA translation controlled by miRNAs (R-HSA-1912412)

Species Homo sapiens


Translation of NOTCH1 mRNA is negatively regulated by microRNAs miR-200B and miR200C (Kong et al. 2010), miR-34 (Li et al. 2009, Ji et al. 2009) and miR-449 (Marcet et al. 2011). These miRNAs bind and cause degradation of NOTCH1 mRNA, resulting in decreased level of NOTCH1 protein product.

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Additional Information
Compartment cytosol , endoplasmic reticulum membrane
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