Reactome: A Curated Pathway Database

c-src mediated regulation of Cx43 function and closure of gap junctions

Stable Identifier
R-HSA-191647
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The kinases c-Src (Giepmans et al. 2001; Sorgen et al. 2004), PKc (Lin et al. 2003) and MAPK (Mograbi et al. 2003) play an essential role in the phosphorylation of Cx which leads to its degradation. c-Src appears to associate with and phosphorylate Cx43 leading to closure of gap junctions. Evidence suggests that v-src may activate MAPK, which in turn phosphorylates Cx43 on serine sites leading to channel gating (Zhou et al. 1999).

Literature References
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Orthologous Events