Reactome: A Curated Pathway Database

c-src mediated regulation of Cx43 function and closure of gap junctions (R-HSA-191647)

Species Homo sapiens

Summation

The kinases c-Src (Giepmans et al. 2001; Sorgen et al. 2004), PKc (Lin et al. 2003) and MAPK (Mograbi et al. 2003) play an essential role in the phosphorylation of Cx which leads to its degradation. c-Src appears to associate with and phosphorylate Cx43 leading to closure of gap junctions. Evidence suggests that v-src may activate MAPK, which in turn phosphorylates Cx43 on serine sites leading to channel gating (Zhou et al. 1999).

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000069