Reactome: A Curated Pathway Database

c-src mediated regulation of Cx43 function and closure of gap junctions

Stable Identifier
R-HSA-191647
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The kinases c-Src (Giepmans et al. 2001; Sorgen et al. 2004), PKc (Lin et al. 2003) and MAPK (Mograbi et al. 2003) play an essential role in the phosphorylation of Cx which leads to its degradation. c-Src appears to associate with and phosphorylate Cx43 leading to closure of gap junctions. Evidence suggests that v-src may activate MAPK, which in turn phosphorylates Cx43 on serine sites leading to channel gating (Zhou et al. 1999).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database