Reactome: A Curated Pathway Database

snRNP Assembly (R-HSA-191859)

Species Homo sapiens


Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA differs from the other snRNAs; it binds seven Sm-like proteins and its assembly does not involve a cytoplasmic phase. The snRNP biogenesis pathway for all of the other snRNAs is complex, involving nuclear export of snRNA, Sm-core assembly in the cytoplasm and re-import of the mature snRNP. The assembly of the snRNA:Sm-core is carried out by the survival of motor neurons (SMN) complex. The SMN complex stringently scrutinizes RNAs for specific features that define them as snRNAs and binds the RNA-binding Sm proteins.

Locations in the PathwayBrowser
Additional Information
GO Biological Process spliceosomal snRNP assembly (0000387)
Literature References
pubMedId Title Journal Year
15130578 Why do cells need an assembly machine for RNA-protein complexes? Trends Cell Biol 2004