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Synthesis of PB1-F2

Stable Identifier
R-HSA-192704
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
Summation

For most influenza A strains (such as PR8), the PB1 mRNA segment produces a second protein, PB1-F2, from the +1 open reading frame (Chen, 2001). PB1-F2 is a pro-apoptotic, mitochondria-localized protein (Chen, 2001; Gibbs, 2003) that oligomerizes (Bruns, 2007) and sensitizes cells to death in concert with the mitochondrial ANT3 and VDAC proteins (Zamarin, 2005).

Literature References
PubMed ID Title Journal Year
11726970 A novel influenza A virus mitochondrial protein that induces cell death Nat Med 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
translation elongation factor activity of 80S ribosome [cytosol]
Physical Entity
Activity
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation