Reactome: A Curated Pathway Database
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Synthesis of PB1-F2

Stable Identifier
R-HSA-192704
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

For most influenza A strains (such as PR8), the PB1 mRNA segment produces a second protein, PB1-F2, from the +1 open reading frame (Chen, 2001). PB1-F2 is a pro-apoptotic, mitochondria-localized protein (Chen, 2001; Gibbs, 2003) that oligomerizes (Bruns, 2007) and sensitizes cells to death in concert with the mitochondrial ANT3 and VDAC proteins (Zamarin, 2005).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
translation elongation factor activity of 80S ribosome [cytosol] 80S ribosome [cytosol] translation elongation factor activity (0003746)
Disease
Diseases
Name Identifier Synonyms
influenza 8469 [Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation]