Reactome: A Curated Pathway Database

Viral Protein Synthesis (R-HSA-192841) [Homo sapiens]

Black Box Event

Spliced and unspliced viral mRNA exported into the cytoplasm are translated by the host cell ribosomal translation machinery (reviewed in Kash, 2006). At least ten viral proteins are synthesized: HA, NA, PB1, PB2, PA, NP, NS1, NEP/NS2 (from spliced NS mRNA), M1, and M2 (from spliced M mRNA). The abundance of each of these proteins is thought to be controlled by differential mRNA abundances and stability (Tekamp, 1980; Hatada, 1989). As the localization of the nascent polypeptides is different between viral proteins with transmembrane domains (HA, NA and M2, which translocate to the ER and are transported through the Golgi to the plasma membrane) and soluble viral proteins (such as NP, the polymerase subunits, and NS1), mechanisms linking the translation of particular viral mRNA with subsequent protein localization rely on signal sequences recognized by the cell.

Additional Information
Compartment cytosol , endoplasmic reticulum membrane
Catalyst Activity
PhysicalEntity Activity Active Units
80S ribosome translation elongation factor activity (0003746)  
Name Identifier Synonyms
influenza 8469 [Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation]
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Regulation type Name
Literature References
pubMedId Title Journal Year
16630668 Hijacking of the host-cell response and translational control during influenza virus infection Virus Res 2006