Reactome: A Curated Pathway Database

Axonal growth inhibition (RHOA activation) (R-HSA-193634)

Species Homo sapiens

Summation

p75NTR can also form a receptor complex with the Nogo receptor (NgR). Such complexes mediates axonal outgrowth inhibitory signals of MDGIs (myelin-derived growth-inhibitors), such as Nogo66, myelin-associated glycoprotein (MAG), and oligodendrocyte myelin glycoprotein (OMGP).

Locations in the PathwayBrowser
Additional Information
GO Biological Process negative regulation of axonogenesis (0050771)
Literature References
pubMedId Title Journal Year
12951563 Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS Nat Rev Neurosci 2003