Reactome: A Curated Pathway Database

p75NTR signals via NF-kB (R-HSA-193639)

Species Homo sapiens


The NF-kB pathway is an important pro-survival signalling pathway activated by mature NGF, but not BDNF or NT-3, through p75NTR. It is unclear whether TRKA activity also affects NF-kB activation.

Locations in the PathwayBrowser
Additional Information
GO Biological Process negative regulation of apoptotic process (0043066)
Literature References
pubMedId Title Journal Year
16997282 NF-kappaB functions in the nervous system: from development to disease Biochem Pharmacol 2006