Reactome: A Curated Pathway Database

NRAGE signals death through JNK

Stable Identifier
R-HSA-193648
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database