Reactome: A Curated Pathway Database

NRAGE signals death through JNK (R-HSA-193648)

Species Homo sapiens


Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.

Locations in the PathwayBrowser
Additional Information
GO Biological Process positive regulation of apoptotic process (0043065)
Cross References
Database Identifier
BioModels Database BIOMD0000000466