Reactome: A Curated Pathway Database

NRAGE signals death through JNK (R-HSA-193648)

Species Homo sapiens

Summation

Once bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pro-apoptotic genes, and directly activates the cell death machinery. Only NGF-bound p75NTR is shown here.

Locations in the PathwayBrowser
Additional Information
GO Biological Process positive regulation of apoptotic process (0043065)
Cross References
Database Identifier
BioModels Database BIOMD0000000466