Reactome: A Curated Pathway Database

p75NTR negatively regulates cell cycle via SC1 (R-HSA-193670) [Homo sapiens]


SC1 (Schwann Cell factor 1; also called PR domain zinc finger protein 4, PRDM4) interacts with an NGF:p75NTR complex and signals cell cycle arrest by regulating the levels of cyclin E.

Additional Information
GO Biological Process negative regulation of cell cycle (0045786)
Literature References
pubMedId Title Journal Year
12371150 Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor Histol Histopathol 2002