p75NTR negatively regulates cell cycle via SC1

Stable Identifier
R-HSA-193670
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

SC1 (Schwann Cell factor 1; also called PR domain zinc finger protein 4, PRDM4) interacts with an NGF:p75NTR complex and signals cell cycle arrest by regulating the levels of cyclin E.

Literature References
PubMed ID Title Journal Year
12371150 Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor Histol Histopathol 2002
Participants
Participant Of
Event Information