Reactome: A Curated Pathway Database

gamma-secretase cleaves the p75NTR transmembrane domain (R-HSA-193682) [Homo sapiens]


Within early endosomes, p75NTR C-Terminal Fragment undergoes processing by gamma-secretase, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such a minimal complex is sufficient for secretase activity, although other components may exist. The p75NTR cleavage by gamma-secretase gives rise to a 20-kD ICD (IntraCellular Domain) fragment, and to a small peptide, the significance of which is unknown but that is analogous to the A-beta peptides generated from amyloid precursor protein. p75NTR ICD may have cytoplasmic and nuclear signalling functions and it is unstable.

Additional Information
Compartment plasma membrane , early endosome
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Catalyst Activity
PhysicalEntity Activity Active Units
gamma-secretase complex endopeptidase activity (0004175)