Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA

Stable Identifier
R-HSA-193736
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
3,7,24THCA-CoA => (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA
ReviewStatus
5/5
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The isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA, catalyzed by 2-methylacyl-CoA racemase, occurs in the peroxisomal matrix.
Literature References
PubMed ID Title Journal Year
10655068 Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy

McLean, BN, Vreken, P, Allen, JT, Brown, AY, Denis, S, Wanders, RJA, Clayton, PT, Graham, A, Waterham, HR, Rees, JE, Ferdinandusse, S

Nat Genet 2000
11060344 Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans

Van Veldhoven, PP, Amery, L, Mannaerts, GP, Fransen, M, De Nys, K

J Lipid Res 2000
7649182 Purification and characterization of an alpha-methylacyl-CoA racemase from human liver

Fingerhut, R, Conzelmann, E, Albers, C, Schmitz, W

Eur J Biochem 1995
Participants
Participates
Catalyst Activity

alpha-methylacyl-CoA racemase activity of AMACR [peroxisomal matrix]

Orthologous Events
Authored
Reviewed
Created
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