Reactome: A Curated Pathway Database

CYP21A2 21-hydroxylates PROG (R-HSA-193964) [Homo sapiens]


Progesterone, NAPDH + H+, and O2 react to form 11-deoxycorticosterone, NADP+ and H2O. This reaction is catalyzed by CYP21A2 associated with the endoplasmic reticulum membrane.

Additional Information
Synonyms 21-hydroxylation of progesterone to form 11-deoxycorticosterone
Compartment cytosol , endoplasmic reticulum membrane
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Catalyst Activity
PhysicalEntity Activity Active Units
CYP21A2 steroid 21-monooxygenase activity (0004509)