Reactome: A Curated Pathway Database
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CYP21A2 21-hydroxylates PROG

Stable Identifier
R-HSA-193964
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
21-hydroxylation of progesterone to form 11-deoxycorticosterone, progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O
Locations in the PathwayBrowser
Summation

Progesterone, NAPDH + H+, and O2 react to form 11-deoxycorticosterone, NADP+ and H2O. This reaction is catalyzed by CYP21A2 associated with the endoplasmic reticulum membrane.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
steroid 21-monooxygenase activity of CYP21A2 [endoplasmic reticulum membrane] CYP21A2 [endoplasmic reticulum membrane] steroid 21-monooxygenase activity (0004509)
Orthologous Events