Reactome: A Curated Pathway Database

CYP21A2 oxidises 17HPROG (R-HSA-193981)

Species Homo sapiens


17-Hydroxyprogesterone, NADPH + H+, and O2 react to form 11-deoxycortisol, NADP+, and H2O. This reaction is catalyzed by CYP21A2 (steroid 21-hydroxylase) associated with the endoplasmic reticulum membrane.

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Additional Information
Synonyms Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol
Compartment cytosol , endoplasmic reticulum membrane
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Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
CYP21A2 steroid 21-monooxygenase activity (0004509)