Reactome: A Curated Pathway Database
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CYP21A2 oxidises 17HPROG

Stable Identifier
R-HSA-193981
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol, 17-hydroxyprogesterone + NADPH + H+ + O2 => 11-deoxycortisol + NADP+ + H2O
Locations in the PathwayBrowser
Summation

17-Hydroxyprogesterone, NADPH + H+, and O2 react to form 11-deoxycortisol, NADP+, and H2O. This reaction is catalyzed by CYP21A2 (steroid 21-hydroxylase) associated with the endoplasmic reticulum membrane.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
steroid 21-monooxygenase activity of CYP21A2 [endoplasmic reticulum membrane] CYP21A2 [endoplasmic reticulum membrane] steroid 21-monooxygenase activity (0004509)
Orthologous Events