17-Hydroxyprogesterone, NADPH + H+, and O2 react to form 11-deoxycortisol, NADP+, and H2O. This reaction is catalyzed by CYP21A2 (steroid 21-hydroxylase) associated with the endoplasmic reticulum membrane.
|Synonyms||Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol|
|Compartment||cytosol , endoplasmic reticulum membrane|
|CYP21A2||steroid 21-monooxygenase activity (0004509)|
|3487786||Structure of human steroid 21-hydroxylase genes||Proc Natl Acad Sci U S A||1986|
|3038528||Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia||EMBO J||1987|