Mineralocorticoid biosynthesis

Stable Identifier
R-HSA-193993
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Mineralocorticoid biosynthesis
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Aldosterone, the major human mineralocorticoid, is synthesized in the zona glomerulosa of the adrenal cortex from pregnenolone. Pregnenolone is converted to progesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. Progesterone is hydroxylated by CYP21A2 to form deoxycorticosterone, which in turn is converted to aldosterone in a three-reaction sequence catalyzed by CYP11B2 (Payne and Hales 2004).
Literature References
PubMed ID Title Journal Year
15583024 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones

Payne, AH, Hales, DB

Endocr Rev 2004
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Event Information
Go Biological Process
mineralocorticoid biosynthetic process (0006705)
Orthologous Events
Mineralocorticoid biosynthesis (Bos taurus)
Mineralocorticoid biosynthesis (Canis familiaris)
Mineralocorticoid biosynthesis (Danio rerio)
Mineralocorticoid biosynthesis (Dictyostelium discoideum)
Mineralocorticoid biosynthesis (Gallus gallus)
Mineralocorticoid biosynthesis (Mus musculus)
Mineralocorticoid biosynthesis (Rattus norvegicus)
Mineralocorticoid biosynthesis (Sus scrofa)
Mineralocorticoid biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2008-10-01)
Reviewed
D'Eustachio, P  (2007-04-21)
Created
Jassal, B  (2007-03-06)
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