Reactome: A Curated Pathway Database
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Mineralocorticoid biosynthesis

Stable Identifier
R-HSA-193993
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

Aldosterone, the major human mineralocorticoid, is synthesized in the zona glomerulosa of the adrenal cortex from pregnenolone. Pregnenolone is converted to progesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. Progesterone is hydroxylated by CYP21A2 to form deoxycorticosterone, which in turn is converted to aldosterone in a three-reaction sequence catalyzed by CYP11B2 (Payne and Hales 2004).

Literature References
Participants
Participant Of
Orthologous Events