Reactome: A Curated Pathway Database

Mineralocorticoid biosynthesis (R-HSA-193993)

Species Homo sapiens

Summation

Aldosterone, the major human mineralocorticoid, is synthesized in the zona glomerulosa of the adrenal cortex from pregnenolone. Pregnenolone is converted to progesterone in two reactions, both catalyzed by 3-beta-hydroxysteroid dehydrogenase/isomerase. Progesterone is hydroxylated by CYP21A2 to form deoxycorticosterone, which in turn is converted to aldosterone in a three-reaction sequence catalyzed by CYP11B2 (Payne and Hales 2004).

Locations in the PathwayBrowser
Additional Information
GO Biological Process mineralocorticoid biosynthetic process (0006705)
Literature References
pubMedId Title Journal Year
15583024 Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones Endocr Rev 2004