Reactome: A Curated Pathway Database

SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (R-HSA-194079)

Species Homo sapiens


A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-8 (SLCO1B3) in the plasma membrane. Glycocholate and taurocholate exist in the blood as complexes with serum albumin, and their uptake by OATP-8 must involve disruption of these complexes, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-8 is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glycocholate and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).

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Additional Information
Compartment plasma membrane
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Catalyst Activity
PhysicalEntity Activity Active Units
SLCO1B3 bile acid transmembrane transporter activity (0015125)
Literature References
pubMedId Title Journal Year
11159893 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Gastroenterology 2001