Reactome: A Curated Pathway Database

SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol (R-HSA-194079) [Homo sapiens]


A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-8 (SLCO1B3) in the plasma membrane. Glycocholate and taurocholate exist in the blood as complexes with serum albumin, and their uptake by OATP-8 must involve disruption of these complexes, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-8 is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glycocholate and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).

Additional Information
Compartment plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
SLCO1B3 bile acid transmembrane transporter activity (0015125)  
Literature References
pubMedId Title Journal Year
11159893 Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Gastroenterology 2001