Reactome: A Curated Pathway Database

SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-8 (SLCO1B3) in the plasma membrane. Glycocholate and taurocholate exist in the blood as complexes with serum albumin, and their uptake by OATP-8 must involve disruption of these complexes, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-8 is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glycocholate and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).

Literature References
Participant Of
This entity is regulated by:
Title Physical Entity Activity
bile acid transmembrane transporter activity of SLCO1B3 [plasma membrane] SLCO1B3 [plasma membrane] bile acid transmembrane transporter activity (0015125)
Orthologous Events