Neurophilin interactions with VEGF and VEGFR

Stable Identifier
R-HSA-194306
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF-A165 and PLGF-2, as well as VEGF-A145 and -C. The Neurolipin receptors appear to act as cofactors for the VEGF receptors, increasing their affinities for specific VEGF ligands, although the importance of this function in vivo remains unclear (Neufeld et al. 2002). Detailed annotation of NRP interactions with VEGF proteins will be covered in future releases.

Literature References
PubMed ID Title Journal Year
12613545 The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF Adv Exp Med Biol 2002
Participants
Participant Of
Orthologous Events