The human genome includes approximately 70 genes that are predicted to encode Rho-specific GTPase Activating Proteins (RhoGAPs). As in the case of GEFs, some RhoGAPs are believed to be highly specific, whereas others are more promiscuous with respect to their target GTPases. Increasing evidence suggests that GAPs are also regulated by external cues in addition to being signal terminators leading to Rho GTPase inactivation. These proteins play important role in many Rho mediated signaling pathways.
Some known GAPs include p190 A, cdGAP, ARAP3, MgcRacGAP, Chimaerin, Nadrin, TCGAP, DLC 1, 2, ArhGAP6, Myosin IXA. These and other GAPs have been implicated in many processes, such as exocytosis, endocytosis, cytokinesis, cell differentiation, migration, neuronal morphogenesis, angiogenesis and tumor suppression. Detailed annotations of the biological role of GAPs in Rho mediated signaling will be available in future releases.
|GAP proteins||GTPase activator activity (0005096)|
|17222083||Current knowledge of the large RhoGAP family of proteins||Biol Cell||2007|
|8288572||Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.||J Biol Chem||1994|
|2825022||A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia||Nature||1987|
|11804589||Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices||Mol Cell||2002|
|9605766||Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP||Cancer Res||1998|
|11431473||Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1||J Biol Chem||2001|