Reactome: A Curated Pathway Database

Degradation of beta-catenin by the destruction complex

Stable Identifier
R-HSA-195253
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006).

Literature References
Participants
Participant Of
hasEvent
Orthologous Events
Cross References
BioModels Database