Reactome: A Curated Pathway Database

Degradation of beta-catenin by the destruction complex (R-HSA-195253)

Species Homo sapiens


The beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-catenin associates with and is phosphorylated by the destruction complex. Phosphorylated beta-catenin is recognized and ubiquitinated by the SCF-beta TrCP ubiquitin ligase complex and is subsequently degraded by the proteasome (reviewed in Kimelman and Xu, 2006).

Locations in the PathwayBrowser
Cross References
Database Identifier
BioModels Database BIOMD0000000149
Literature References
pubMedId Title Journal Year
17143292 beta-catenin destruction complex: insights and questions from a structural perspective Oncogene 2006