Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol

Stable Identifier
R-HSA-195690
Type
Reaction
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Zymosterol => cholesta-7,24-dien-3beta-ol
Locations in the PathwayBrowser
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Summation

Isomerization of zymosterol to cholesta-7,24-dien-3beta-ol is catalyzed by EBP in the endoplasmic reticulum. The biochemical details of the reaction have been established through studies of purified rat EBP; the role of the human enzyme has been established through studies of patients deficient in it (Derry et al. 1999; Braverman et al. 1999).

Literature References
Participants
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Output
Participant Of
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Catalyst Activity
Catalyst Activity
Title
steroid delta-isomerase activity of EBP [endoplasmic reticulum membrane]
Physical Entity
EBP [endoplasmic reticulum membrane]
Activity
steroid delta-isomerase activity (0004769)
Orthologous Events
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Arabidopsis thaliana)
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Bos taurus)
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Canis familiaris)
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Dictyostelium discoideum)
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Mus musculus)
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Oryza sativa)
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Rattus norvegicus)
Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol (Sus scrofa)
Cross References
Rhea