Reactome: A Curated Pathway Database

Formation of annular gap junctions (R-HSA-196025) [Homo sapiens]


Gap junction plaque internalization and the disruption cell communication requires a reorganization of Cx molecular interactions. Proteins including Dab-2, AP-2, Dynamin and Myosin VI associate with gap junction plaques permitting the internalisation of plaques after clathrin association (Piehl et al., 2007).

Until now, two kinds of annular gap junctions have been described. The first is a small vesicle like structure which permits gap junction plaque renewal without arrest of functionality [Jordan et al., 2001]. The second is a large annular structure, composed primarily of the junctional plaques of two adjacent cells (Jordan et al., 2001; Segretain et al., 2004).

Literature References
pubMedId Title Journal Year
17108328 Internalization of Large Double-Membrane Intercellular Vesicles by a Clathrin-dependent Endocytic Process Mol Biol Cell 2007