Reactome: A Curated Pathway Database

Beta-catenin phosphorylation cascade (R-HSA-196299) [Homo sapiens]


Degradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated phosphorylation at Thr41, Ser37 and Ser33 (Amit et al., 2002 ; Lui et al., 2002).

Additional Information
Compartment cytosol
Cross References
Database Identifier
BioModels Database BIOMD0000000149