Reactome: A Curated Pathway Database

Beta-catenin phosphorylation cascade

Stable Identifier
R-HSA-196299
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Degradation of beta-catenin is initiated following amino-terminal serine/threonine phosphorylation. Phosphorylation of B-catenin at S45 by CK1 alpha primes the subsequent sequential GSK-3-mediated phosphorylation at Thr41, Ser37 and Ser33 (Amit et al., 2002 ; Lui et al., 2002).

Literature References
Participants
Participant Of
Orthologous Events
Cross References
BioModels Database