Reactome: A Curated Pathway Database

Metabolism of folate and pterines (R-HSA-196757) [Homo sapiens]


Folates are essential cofactors that provide one-carbon moieties in various states of reduction for biosynthetic reactions. Processes annotated here include transport reactions by which folates are taken up by cells and moved intracellularly, folate conjugation with glutamate (required for folate retention within a cell), and some of the key reactions in the generation of reduced folates and one-carbon derivatives of folate.

Additional Information
GO Biological Process folic acid metabolic process (0046655)
Cross References
Database Identifier
BioModels Database BIOMD0000000268
Literature References
pubMedId Title Journal Year
11001804 Folic acid: nutritional biochemistry, molecular biology, and role in disease processes Mol Genet Metab 2000
10466189 Folate and vitamin B12 Proc Nutr Soc 1999