Reactome: A Curated Pathway Database

Signaling by NOTCH4 (R-HSA-1980150)

Species Homo sapiens


Similar to NOTCH1, NOTCH4 is activated by delta-like and jagged ligands (DLL/JAG) expressed in trans on a neighboring cell. The activation triggers cleavage of NOTCH4, first by ADAM10 at the S2 cleavage site, then by gamma-secretase at the S3 cleavage site, resulting in the release of the intracellular domain of NOTCH4, NICD4, into the cytosol. NICD4 subsequently traffics to the nucleus where it acts as a transcriptional regulator.

Locations in the PathwayBrowser
Additional Information
Compartment plasma membrane , cytosol , nucleoplasm
GO Biological Process Notch signaling pathway (0007219)