Reactome: A Curated Pathway Database

PI3K/AKT activation (R-HSA-198203)

Species Homo sapiens


PI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell death and survival. In addition, it may also use metabolic pathways to regulate cell survival.The PI3K/AKT pathway also affects axon diameter and branching (Marcus et al, 2002) and regulates small G proteins like RhoA (Vanhaesebroeck, B and Waterman, MD, 1999), which control the behaviour of the F-actin cytoskeleton. Moreover, through its connection with the TOR pathway, it promotes translation of a subset of mRNAs.

Locations in the PathwayBrowser
Additional Information
GO Biological Process phosphatidylinositol-mediated signaling (0048015)
Literature References
pubMedId Title Journal Year
12123609 Raf and akt mediate distinct aspects of sensory axon growth Neuron 2002
10579926 Signaling by distinct classes of phosphoinositide 3-kinases Exp Cell Res 1999