We will be undergoing a brief scheduled maintenance at Monday Jan 22 at 10AM EST - you may experience some outages

We will be undergoing a scheduled maintenance at Monday Jan 22 at 10AM EST

PIP3 recruits PDK1 and AKT to the membrane

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Phosphatidylinositides generated by PI3K recruit phosphatidylinositide-dependent protein kinase 1 (PDK1) and AKT (also known as protein kinase B) to the membrane, through their PH (pleckstrin-homology) domains. The binding of PIP3 to the PH domain of AKT is the rate-limiting step in AKT activation. In mammals there are three AKT isoforms (AKT1-3) encoded by three separate genes. The three isoforms share a high degree of amino acid identity and have indistinguishable substrate specificity in vitro. However, isoform-preferred substrates in vivo cannot be ruled out. The relative expression of the three isoforms differs in different mammalian tissues: AKT1 is the predominant isoform in the majority of tissues, AKT2 is the predominant isoform in insulin-responsive tissues, and AKT3 is the predominant isoform in brain and testes. All 3 isoforms are expressed in human and mouse platelets (Yin et al. 2008; O'Brien et al. 2008). Note: all data in the pathway refer to AKT1, which is the most studied.

Literature References
PubMed ID Title Journal Year
12167717 Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B Mol Cell Biol 2002
Participant Of
This entity is regulated by
Orthologous Events