Reactome: A Curated Pathway Database

AKT phosphorylates targets in the cytosol

Stable Identifier
R-HSA-198323
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Following activation, AKT can phosphorylate an array of target proteins in the cytoplasm, many of which are involved in cell survival control. Phosphorylation of TSC2 feeds positively to the TOR kinase, which, in turn, contributes to AKT activation (positive feedback loop).

Participants
Participant Of
Orthologous Events
Cross References
BioModels Database