Reactome: A Curated Pathway Database

Nuclear Events (kinase and transcription factor activation) (R-HSA-198725)

Species Homo sapiens


An important function of the kinase cascade triggered by neurotrophins is to induce the phosphorylation and activation of transcription factors in the nucleus to initiate new programs of gene expression. Transcription factors directly activated by neurotrophin signalling are responsible for induction of immediate-early genes, many of which are transcription factors. These in turn are involved in the induction of delayed-early genes.

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Literature References
pubMedId Title Journal Year
8833451 Intracellular signaling pathways activated by neurotrophic factors Annu Rev Neurosci 1996