Reactome: A Curated Pathway Database
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Nuclear Events (kinase and transcription factor activation)

Stable Identifier
R-HSA-198725
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

An important function of the kinase cascade triggered by neurotrophins is to induce the phosphorylation and activation of transcription factors in the nucleus to initiate new programs of gene expression. Transcription factors directly activated by neurotrophin signalling are responsible for induction of immediate-early genes, many of which are transcription factors. These in turn are involved in the induction of delayed-early genes.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events