Reactome | GSTO dimers reduce DeHA to AscH-

GSTO dimers reduce DeHA to AscH-

Stable Identifier

R-HSA-198813

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

dehydroascorbate (DHA) + 2 glutathione (GSH) => ascorbate + oxidized glutathione (GSSG)

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic omega class glutathione transferases (GSTO1 and GSTO2) catalyze the reaction of dehydroascorbate (DeHA) and glutathione (GSH) to form ascorbate (AscH-) and oxidized glutathione (GSSG). The GSTO enzymes occur as homodimers (Board et al. 2000), and while both have dehydroascorbate reductase activity in vitro, that of GSTO2 is much greater than that of GSTO1 (Schmuck et al. 2005). Polymorphisms affecting the activities of the two enzymes have been described (Whitbread et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15970797	Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases Whitbread, AK, Schmuck, EM, Blackburn, AC, Tetlow, N, Masoumi, A, Cavanaugh, JA, Board, PG	Pharmacogenet Genomics	2005
10783391	Identification, characterization, and crystal structure of the Omega class glutathione transferases Danley, DE, Rosner, MH, Schulte, GK, Hoth, LR, Perregaux, DE, Easteal, S, Chrunyk, BA, Griffor, MC, Geoghegan, KF, Gabel, CA, Pandit, J, Jermiin, LS, Chelvanayagam, G, Coggan, M, Kamath, AV, Board, PG	J Biol Chem	2000