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trans-Golgi Network Vesicle Budding
Stable Identifier
R-HSA-199992
DOI
10.3180/REACT_11235.3
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
trans-Golgi Network Vesicle Budding (Homo sapiens)
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After passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membrane. There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat.
Literature References
PubMed ID
Title
Journal
Year
11252894
Three ways to make a vesicle
Kirchhausen, Tomas
Nat Rev Mol Cell Biol
2000
Participants
Events
trans-Golgi Network Coat Activation
(Homo sapiens)
Golgi Associated Vesicle Biogenesis
(Homo sapiens)
Lysosome Vesicle Biogenesis
(Homo sapiens)
Vamp2 associated secretory vesicle to plasma membrane transport
(Homo sapiens)
Vamp7 associated Lysosome to Plasma membrane transport
(Homo sapiens)
Vamp8 associated secretory vesicle to plasma membrane transport
(Homo sapiens)
Participates
as an event of
Membrane Trafficking (Homo sapiens)
Event Information
Go Biological Process
post-Golgi vesicle-mediated transport (0006892)
Orthologous Events
trans-Golgi Network Vesicle Budding (Bos taurus)
trans-Golgi Network Vesicle Budding (Caenorhabditis elegans)
trans-Golgi Network Vesicle Budding (Canis familiaris)
trans-Golgi Network Vesicle Budding (Danio rerio)
trans-Golgi Network Vesicle Budding (Dictyostelium discoideum)
trans-Golgi Network Vesicle Budding (Drosophila melanogaster)
trans-Golgi Network Vesicle Budding (Gallus gallus)
trans-Golgi Network Vesicle Budding (Mus musculus)
trans-Golgi Network Vesicle Budding (Plasmodium falciparum)
trans-Golgi Network Vesicle Budding (Rattus norvegicus)
trans-Golgi Network Vesicle Budding (Saccharomyces cerevisiae)
trans-Golgi Network Vesicle Budding (Schizosaccharomyces pombe)
trans-Golgi Network Vesicle Budding (Sus scrofa)
trans-Golgi Network Vesicle Budding (Xenopus tropicalis)
Authored
Gillespie, ME (2008-05-22)
Reviewed
Simpson, JC (2009-08-28)
Rush, MG (2008-01-11)
Created
Gillespie, ME (2007-07-14)
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