Reactome: A Curated Pathway Database
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Creatine transport across the plasma membrane

Stable Identifier
R-HSA-200396
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The SLC6A8 transport protein associated with the plasma membrane mediates the uptake of extracellular creatine and a sodium ion (Sora et al. 1994). Molecular and biochemical studies of patients deficient in SLC6A8 protein confirm this function in vivo (e.g., Salomons et al. 2003).

Literature References
PubMed ID Title Journal Year
7945388 The cloning and expression of a human creatine transporter Biochem Biophys Res Commun 1994
12889669 X-linked creatine transporter defect: an overview J Inherit Metab Dis 2003
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
creatine:sodium symporter activity of SLC6A8-like proteins [plasma membrane] SLC6A8-like proteins [plasma membrane] creatine:sodium symporter activity (0005309)
Orthologous Events