Reactome: A Curated Pathway Database

Creatine transport across the plasma membrane (R-HSA-200396) [Homo sapiens]


The SLC6A8 transport protein associated with the plasma membrane mediates the uptake of extracellular creatine and a sodium ion (Sora et al. 1994). Molecular and biochemical studies of patients deficient in SLC6A8 protein confirm this function in vivo (e.g., Salomons et al. 2003).

Additional Information
Compartment plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
SLC6A8-like proteins creatine:sodium symporter activity (0005309)  
Literature References
pubMedId Title Journal Year
7945388 The cloning and expression of a human creatine transporter Biochem Biophys Res Commun 1994
12889669 X-linked creatine transporter defect: an overview J Inherit Metab Dis 2003