Reactome: A Curated Pathway Database

Creatine transport across the plasma membrane (R-HSA-200396)

Species Homo sapiens


The SLC6A8 transport protein associated with the plasma membrane mediates the uptake of extracellular creatine and a sodium ion (Sora et al. 1994). Molecular and biochemical studies of patients deficient in SLC6A8 protein confirm this function in vivo (e.g., Salomons et al. 2003).

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Additional Information
Compartment plasma membrane
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Catalyst Activity
PhysicalEntity Activity Active Units
SLC6A8-like proteins creatine:sodium symporter activity (0005309)
Literature References
pubMedId Title Journal Year
7945388 The cloning and expression of a human creatine transporter Biochem Biophys Res Commun 1994
12889669 X-linked creatine transporter defect: an overview J Inherit Metab Dis 2003