Reactome: A Curated Pathway Database

Import of palmitoyl-CoA into the mitochondrial matrix

Stable Identifier
R-HSA-200425
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The mitochondrial carnitine system catalyzes the transport of long-chain fatty acids into the mitochondrial matrix where they undergo beta oxidation. This transport system consists of the malonyl-CoA sensitive carnitine palmitoyltransferase I (CPT-I) localized in the mitochondrial outer membrane, the carnitine:acylcarnitine translocase, an integral inner membrane protein, and carnitine palmitoyltransferase II localized on the matrix side of the inner membrane. (Kerner and Hoppel, 2000).

Literature References
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