Reactome: A Curated Pathway Database

SKI complexes with the Smad complex, suppressing BMP2 signalling (R-HSA-201423) [Homo sapiens]


SKI and SKIL (SNO) are able to recruit NCOR and possibly other transcriptional repressors to SMAD2/3:SMAD4 complex, inhibiting SMAD2/3:SMAD4-mediated transcription (Sun et al. 1999, Luo et al. 1999, Strochein et al. 1999). Experimental findings suggest that SMAD2 and SMAD3 may target SKI and SKIL for degradation (Strochein et al. 1999, Sun et al. 1999 PNAS, Bonni et al. 2001), and that the ratio of SMAD2/3 and SKI/SKIL determines the outcome (inhibition of SMAD2/3:SMAD4-mediated transcription or degradation of SKI/SKIL). SKI and SKIL are overexpressed in various cancer types and their oncogenic effect is connected with their ability to inhibit signaling by TGF-beta receptor complex.

Additional Information
Compartment nucleoplasm
Literature References
pubMedId Title Journal Year
11121043 Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells Proc Natl Acad Sci U S A 2000