Reactome: A Curated Pathway Database
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Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling

Stable Identifier
R-HSA-201425
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The nuclear R-SMAD:Co-SMAD complex recruits ubiquitin conjugating enzymes, such as UBE2D1 and UBE2D3, that ubiquitinate the complex and eventually lead to its proteasomal degradation. This provides an end point to the signaling pathway.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
ubiquitin-protein transferase activity of Nuclear ubiquitin ligase [nucleoplasm] Nuclear ubiquitin ligase [nucleoplasm] ubiquitin-protein transferase activity (0004842)
Orthologous Events