The phosphorylated-r-SMAD1/5/8:Co-SMAD complex rapidly translocates to the nucleus where it binds directly to DNA and interacts with a plethora of transcription co-factors. Regulation of target gene expression can be either positive or negative. A classic example of a target gene of the pathway are the genes encoding for i-SMADs. Thus, BMP2/SMAD signalling induces the expression of the negative regulators of the pathway (a negative feedback loop).
|12592392||An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity||Oncogene||2003|
|11509558||Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals||J Biol Chem||2001|
|12821673||A novel nuclear export signal in Smad1 is essential for its signaling activity||J Biol Chem||2003|