Reactome: A Curated Pathway Database

TCF dependent signaling in response to WNT (R-HSA-201681) [Homo sapiens]


19 WNT ligands and 10 FZD receptors have been identified in human cells; interactions amongst these ligands and receptors vary in a developmental and tissue-specific manner and lead to activation of so-called 'canonical' and 'non-canonical' WNT signaling. In the canonical WNT signaling pathway, binding of a WNT ligand to the Frizzled (FZD) and lipoprotein receptor-related protein (LRP) receptors results in the inactivation of the destruction complex, the stabilization and nuclear translocation of beta-catenin and subsequent activation of T-cell factor/lymphoid enhancing factor (TCF/LEF)-dependent transcription. Transcriptional activation in response to canonical WNT signaling controls processes such as cell fate, proliferation and self renewal of stem cells, as well as contributing to oncogenesis (reviewed in MacDonald et al, 2009; Saito-Diaz et al, 2013; Kim et al, 2013).

Additional Information
Compartment cytosol , extracellular region , nucleoplasm
Cross References
Database Identifier
BioModels Database BIOMD0000000149
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Regulation type Name
Literature References
pubMedId Title Journal Year
19619488 Wnt/beta-catenin signaling: components, mechanisms, and diseases Dev Cell 2009
23256519 The way Wnt works: Components and mechanism Growth Factors 2013
23343194 Wnt/?-catenin signalling: from plasma membrane to nucleus Biochem. J. 2013