Reactome: A Curated Pathway Database

The ligand trap binds the ligand BMP2, blocking BMP signalling (R-HSA-201810) [Homo sapiens]


BMP ligand traps are cystine-knot containing proteins which bind BMPs and antagonise their actions. They are active during organ development and morphogenesis. Different BMP ligand traps show specific spatio-temporal expression during development, and selective activity against specific BMP ligands.

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Compartment extracellular region
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Literature References
pubMedId Title Journal Year
17029022 Bone morphogenetic proteins and their antagonists Rev Endocr Metab Disord 2006