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Translocation of PDK1 to Plasma membrane

Stable Identifier
R-HSA-202164
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PI3K activation results in recruitment of the serine/threonine kinase PDK1, (3-phosphoinositide-dependent kinase 1) to the plasma membrane where PDK1 subsequently phosphorylates and activates AKT. PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane. PDK1 seems to exist in an active, phosphorylated configuration under basal conditions (Vanhaesebroeck & Alessi 2000).

Literature References
PubMed ID Title Journal Year
10698680 The PI3K-PDK1 connection: more than just a road to PKB Biochem J 2000
Participants
Participant Of
Orthologous Events