Translocation of PDK1 to Plasma membrane

Stable Identifier
R-HSA-202164
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Translocation of PDK1 to Plasma membrane
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PI3K activation results in recruitment of the serine/threonine kinase PDK1, (3-phosphoinositide-dependent kinase 1) to the plasma membrane where PDK1 subsequently phosphorylates and activates AKT. PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane. PDK1 seems to exist in an active, phosphorylated configuration under basal conditions (Vanhaesebroeck & Alessi 2000).
Literature References
PubMed ID Title Journal Year
10698680 The PI3K-PDK1 connection: more than just a road to PKB

Vanhaesebroeck, B, Alessi, DR

Biochem J 2000
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Orthologous Events
Translocation of PDK1 to Plasma membrane (Bos taurus)
Translocation of PDK1 to Plasma membrane (Caenorhabditis elegans)
Translocation of PDK1 to Plasma membrane (Canis familiaris)
Translocation of PDK1 to Plasma membrane (Danio rerio)
Translocation of PDK1 to Plasma membrane (Dictyostelium discoideum)
Translocation of PDK1 to Plasma membrane (Drosophila melanogaster)
Translocation of PDK1 to Plasma membrane (Gallus gallus)
Translocation of PDK1 to Plasma membrane (Mus musculus)
Translocation of PDK1 to Plasma membrane (Plasmodium falciparum)
Translocation of PDK1 to Plasma membrane (Rattus norvegicus)
Translocation of PDK1 to Plasma membrane (Saccharomyces cerevisiae)
Translocation of PDK1 to Plasma membrane (Schizosaccharomyces pombe)
Translocation of PDK1 to Plasma membrane (Sus scrofa)
Translocation of PDK1 to Plasma membrane (Xenopus tropicalis)
Authored
Garapati, P V  (2008-01-24)
Rudd, C.E.  (2008-01-24)
de Bono, B  (2008-01-24)
Reviewed
Trowsdale, J  (2008-02-26)
Created
Garapati, P V  (2007-10-29)
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