Reactome: A Curated Pathway Database

Translocation of PDK1 to Plasma membrane (R-HSA-202164) [Homo sapiens]


PI3K activation results in recruitment of the serine/threonine kinase PDK1, (3-phosphoinositide-dependent kinase 1) to the plasma membrane where PDK1 subsequently phosphorylates and activates AKT. PDK1 with its PH domain binds to either PIP3 or PIP2 and is translocated to the plasma membrane. PDK1 seems to exist in an active, phosphorylated configuration under basal conditions (Vanhaesebroeck & Alessi 2000).

Additional Information
Compartment cytosol , plasma membrane
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Literature References
pubMedId Title Journal Year
10698680 The PI3K-PDK1 connection: more than just a road to PKB Biochem J 2000