Reactome: A Curated Pathway Database

Phosphorylation of ZAP-70 by Lck (R-HSA-202168) [Homo sapiens]


In ZAP-70 there are multiple phosphorylation sites (Y292, Y315, Y319, Y492, Y493) which have both positive and negative regulatory effect on its catalytic activity. Tyrosine 493 is a conserved regulatory site found within the activation loop of the kinase domain. This site has shown to be a positive regulatory site required for ZAP-70 kinase activity and is phosphorylated by Lck. This phosphorylation contribute to the active conformation of the catalytic domain.

Additional Information
Compartment cytosol , plasma membrane