Reactome: A Curated Pathway Database

Activation of ZAP-70 (R-HSA-202174) [Homo sapiens]


Later ZAP-70 undergoes trans-autophosphorylation at Y315 and Y319. These sites appear to be positive regulatory sites. ZAP-70 achieve its full activation after the trans-autophosphorylation. Activated ZAP-70 phosphorylates T-cell-specific adaptors, such as LAT and SLP-76 leading to the recruitment and activation of other kinase families and enzymes, resulting in secondary messenger generation and culminating in T cell activation.

Additional Information
Compartment cytosol , plasma membrane
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
phospho tyrosine ZAP-70 protein tyrosine kinase activity (0004713)