Reactome: A Curated Pathway Database

Activation of ZAP-70

Stable Identifier
R-HSA-202174
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Later ZAP-70 undergoes trans-autophosphorylation at Y315 and Y319. These sites appear to be positive regulatory sites. ZAP-70 achieve its full activation after the trans-autophosphorylation. Activated ZAP-70 phosphorylates T-cell-specific adaptors, such as LAT and SLP-76 leading to the recruitment and activation of other kinase families and enzymes, resulting in secondary messenger generation and culminating in T cell activation.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of phospho tyrosine ZAP-70 [plasma membrane] phospho tyrosine ZAP-70 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events