Later ZAP-70 undergoes trans-autophosphorylation at Y315 and Y319. These sites appear to be positive regulatory sites. ZAP-70 achieve its full activation after the trans-autophosphorylation. Activated ZAP-70 phosphorylates T-cell-specific adaptors, such as LAT and SLP-76 leading to the recruitment and activation of other kinase families and enzymes, resulting in secondary messenger generation and culminating in T cell activation.
|phospho tyrosine ZAP-70||protein tyrosine kinase activity (0004713)|
|8520027||The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes||Semin Immunol||1995|
|9850860||The Syk family of protein tyrosine kinases in T-cell activation and development||Immunol Rev||1998|