Reactome: A Curated Pathway Database

3x4Hyp-COL2A1(26-1487) (R-HSA-2022096) [Homo sapiens]

Reference Gene Product
Locations in the PathwayBrowser
Other forms of this molecule
3x4Hyp-COL2A1(182-1487) (extracellular region) GlcGalHyl-COL2A1(26-1487) (extracellular region) 3x4Hyp-GlcGalHyl-COL2A1(26-1487) (extracellular region)
GlcGalHyl-COL2A1(182-1487) (extracellular region) GalHyl-COL2A1(26-1487) (endoplasmic reticulum lumen) COL2A1(182-1487) (extracellular region)
COL2A1(26-1487) (extracellular region) 3x4Hyp-3Hyp-GalHyl-COL2A1(182-1241) (extracellular region) 3x4Hyp-3Hyp-COL2A1(26-1487) (extracellular region)
3x4Hyp-GalHyl-COL2A1(182-975) (extracellular region) 3x4Hyp-GlcGalHyl-COL2A1(182-1487) (extracellular region) 3x4Hyp-GalHyl-COL2A1(182-1241) (extracellular region)
3x4Hyp-GalHyl-COL2A1(976-1241) (extracellular region) 3x4Hyp-3Hyp-5Hyl-COL2A1(182-1241) (extracellular region) 3x4Hyp-3Hyp-COL2A1(182-1487) (extracellular region)
3x4Hyp-3Hyp-COL2A1(976-1241) (extracellular region) 3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1241) (extracellular region) 3x4Hyp-3Hyp-GalHyl-COL2A1(976-1241) (extracellular region)
3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487) (extracellular region) GlcGalHyl-COL2A1(182-975) (extracellular region) 3x4Hyp-GalHyl-COL2A1(26-1487) (endoplasmic reticulum lumen)
3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) (endoplasmic reticulum lumen) 3x4Hyp-3Hyp-COL2A1(182-975) (extracellular region) 3x4Hyp-GlcGalHyl-COL2A1(182-1241) (extracellular region)
3x4Hyp-3Hyp-5Hyl-COL2A1(182-975) (extracellular region) COL2A1(26-1487) (endoplasmic reticulum lumen) GalHyl-COL2A1(976-1241) (extracellular region)
3x4Hyp-5Hyl-COL2A1(182-1487) (extracellular region) 5Hyl-COL2A1(26-1487) (endoplasmic reticulum lumen) 3x4Hyp-5Hyl-COL2A1(26-1487) (extracellular region)
3x4Hyp-GalHyl-COL2A1(26-1487) (extracellular region) COL2A1(182-1241) (extracellular region) GlcGalHyl-COL2A1(182-1241) (extracellular region)
GalHyl-COL2A1(182-1487) (extracellular region) 3x4Hyp-3Hyp-5Hyl-COL2A1(182-1487) (extracellular region) 3x4Hyp-COL2A1(976-1241) (extracellular region)
5Hyl-COL2A1(976-1241) (extracellular region) 3x4Hyp-GalHyl-COL2A1(182-1487) (extracellular region) 3x4Hyp-5Hyl-COL2A1(182-1241) (extracellular region)
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(26-1487) (endoplasmic reticulum lumen) 3x4Hyp-5Hyl-COL2A1(182-975) (extracellular region) GalHyl-COL2A1(182-1241) (extracellular region)
5Hyl-COL2A1(26-1487) (extracellular region) 3x4Hyp-GlcGalHyl-COL2A1(182-975) (extracellular region) 3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) (extracellular region)
3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-1487) (extracellular region) 3x4Hyp-COL2A1(182-1241) (extracellular region) 3x4Hyp-COL2A1(182-975) (extracellular region)
3x4Hyp-3Hyp-5Hyl-COL2A1(26-1487) (endoplasmic reticulum lumen) 5Hyl-COL2A1(182-1487) (extracellular region) 3x4Hyp-COL2A1(26-1487) (extracellular region)
COL2A1(182-975) (extracellular region) 3x4Hyp-3Hyp-GlcGalHyl-COL2A1(26-1487) (extracellular region) 3x4Hyp-5Hyl-COL2A1(976-1241) (extracellular region)
5Hyl-COL2A1(182-1241) (extracellular region) GlcGalHyl-COL2A1(26-1487) (endoplasmic reticulum lumen) 3x4Hyp-3Hyp-GalHyl-COL2A1(26-1487) (extracellular region)
3x4Hyp-5Hyl-COL2A1(26-1487) (endoplasmic reticulum lumen) 3x4Hyp-3Hyp-5Hyl-COL2A1(976-1241) (extracellular region) GalHyl-COL2A1(182-975) (extracellular region)
3x4Hyp-3Hyp-COL2A1(182-1241) (extracellular region) 3x4Hyp-3Hyp-GlcGalHyl-COL2A1(976-1241) (extracellular region) 3x4Hyp-3Hyp-GlcGalHyl-COL2A1(182-975) (extracellular region)
3x4Hyp-3Hyp-COL2A1(26-1487) (endoplasmic reticulum lumen) 3x4Hyp-3Hyp-GalHyl-COL2A1(182-975) (extracellular region) COL2A1(976-1241) (extracellular region)
5Hyl-COL2A1(182-975) (extracellular region) GlcGalHyl-COL2A1(976-1241) (extracellular region) GalHyl-COL2A1(26-1487) (extracellular region)
3x4Hyp-GlcGalHyl-COL2A1(976-1241) (extracellular region) 3x4Hyp-GlcGalHyl-COL2A1(26-1487) (endoplasmic reticulum lumen)
Additional Information
External reference name COL2A1
External reference id P02458
Synonyms 4-hydroxyprolyl collagen alpha-1(II) propeptide, Collagen type II alpha 1 chain
Compartment endoplasmic reticulum lumen
Other Identifiers
 0002260373  0005130121  11757309_a_at  1280  1U5M
 213492_at  217404_s_at  2FSE  2SEB  37605_at
 598_at  85915_at  A_23_P500464  AAA51997  AAA52038
 AAA52039  AAA52051  AAA58428  AAA73873  AAB60370
 AAC41772  AAD15287  AAH07252  AAI16450  AAP35869
 AC004801  BC007252  BC116449  BT007205  CAA25092
 CAA26223  CAA26224  CAA26225  CAA26226  CAA26227
 CAA29604  CAA32030  CAA34278  CAA34279  CAA34280
 CAA34281  CAA34282  CAA34283  CAA34284  CAA34488
 CAA34683  CAA40330  CAB002214  CCDS41778  CCDS8759
 COL2A1  COL2A1-001  COL2A1-008  ENSG00000139219  ENSP00000338213
 ENSP00000369889  ENST00000337299  ENST00000380518  EntrezGene:1280  GE57600
 HGNC:2200  HPA045939  Hs.408182  Hs.81343.0.S2_3p_at  Hs.81343.1.S1_3p_a_at
 ILMN_1674785  ILMN_1686538  ILMN_1742840  IPR000885  IPR001007
 IPR008160  J00116  J00116_s_at  L00977  L10347
 M12048  M25655  M25656  M25698  M25728
 M25730  M27468  M32168  M60299  M60299_at
 M63281  M64345  MIM:120140  NM_001844  NM_033150
 NP_001835  NP_149162  OTTHUMP00000195063  OTTHUMP00000195071  PF00093
 PF01391  PF01410  PH_hs_0024730  R-HSA-1266738  R-HSA-1280218
 R-HSA-1442490  R-HSA-1474228  R-HSA-1474244  R-HSA-1474290  R-HSA-162582
 R-HSA-1650814  R-HSA-168256  R-HSA-186797  R-HSA-198933  R-HSA-2022090
 R-HSA-216083  R-HSA-3000171  R-HSA-3000178  R-HSA-375165  R-HSA-419037
 R-HSA-422475  SM00038  SM00214  U15195  uc001rqu.4
 uc001rqv.4  UPI0000246C60  UPI0000D79713  X00339  X02371
 X02372  X02373  X02374  X02375  X02376
 X02377  X02378  X06268  X06268_at  X13783
 X16158  X16468  X16711  X57010  X58709
 XM_006719242  XM_011537928  XM_011537929  XM_011537930  XM_011537931
 XM_011537932  XM_011537933  XM_011537934  XP_006719305  XP_011536230
 XP_011536231  XP_011536232  XP_011536233  XP_011536234  XP_011536235
 XP_011536236
Secondary Identifiers CO2A1_HUMAN, A6NGA0, Q12985, Q14009, Q14044, Q14045, Q14046, Q14047, Q14056, Q14058, Q16672, Q1JQ82, Q2V4X7, Q6LBY1, Q6LBY2, Q6LBY3, Q96IT5, Q99227, Q9UE38, Q9UE39, Q9UE40, Q9UE41, Q9UE42, Q9UE43
Gene Names COL2A1
Chain signal peptide:1-25, propeptide:26-181, chain:182-1241, chain:1242-1487
This entry is a component of:
hasMember
hasCandidate
Reference Genes
Database Identifier
dbSNP Gene 1280
CTD Gene 1280
BioGPS Gene 1280
NCBI Gene 1280
ENSEMBL ENSG00000139219
KEGG Gene COL2A1
Orphanet 15769
Reference Transcripts
Database Identifier
RefSeq NM_001844
Cross References
Database Identifier
RefSeq NP_001835, NP_149162
DOCK Blaster 1U5M, 2SEB, 2FSE
PRO P02458
GeneCards P02458
UCSC human P02458
Protein Data Bank 1U5M, 2SEB, 2FSE
ModifiedResidues
Name Coordinate Modification PsiMod Name PsiMod Identifier PsiMod Definition
(2S,4R)-4-hydroxyproline at unknown position (2S,4R)-4-hydroxyproline 00039 A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
(2S,4R)-4-hydroxyproline at unknown position (2S,4R)-4-hydroxyproline 00039 A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline
(2S,4R)-4-hydroxyproline at unknown position (2S,4R)-4-hydroxyproline 00039 A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline