Reactome: A Curated Pathway Database

Dephosphorylation of Lck-pY505 by CD45 (R-HSA-202214)

Species Homo sapiens


TCR stimulation induce the transient dephosphorylation of PAG thereby release the Csk from its plasma membrane anchor. The release of Csk from its proximity with Lck may serve to facilitate the activation of Lck. The inactive Lck is dephosphorylated by CD45 phosphatase. CD45 specifically dephosphorylates the Y505 residue of Lck and induce the active open conformation.

Locations in the PathwayBrowser
Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
PTPRC protein tyrosine phosphatase activity (0004725)
Literature References
pubMedId Title Journal Year
11827988 Adapters in lymphocyte signaling J Clin Invest 2002