Dephosphorylation of Lck-pY505 by CD45
Species Homo sapiens
TCR stimulation induce the transient dephosphorylation of PAG thereby release the Csk from its plasma membrane anchor. The release of Csk from its proximity with Lck may serve to facilitate the activation of Lck. The inactive Lck is dephosphorylated by CD45 phosphatase. CD45 specifically dephosphorylates the Y505 residue of Lck and induce the active open conformation.
Locations in the PathwayBrowser
Immune System(Homo sapiens)