Reactome: A Curated Pathway Database

Phosphorylation of SLP-76 (R-HSA-202216) [Homo sapiens]


Once SLP-76 is recruited to Gads its rapidly phosphorylated on the tyrosine residues in the N-terminal acidic domain. This domain contains three tyrosine phosphorylation sites, Y113, Y128 and Y145. These tyrosine residues are phosphorylated by tyrosine kinase ZAP-70 and these phosphorylated tyrosine residues provide the binding site for the SH2 domains of the incoming signaling proteins like Vav, Itk and PLC-gamma1.

Additional Information
Compartment cytosol , plasma membrane
Catalyst Activity
PhysicalEntity Activity Active Units
Activated ZAP-70 protein tyrosine kinase activity (0004713)
Literature References
pubMedId Title Journal Year
17652306 Keeping the (kinase) party going: SLP-76 and ITK dance to the beat Sci STKE 2007