Reactome: A Curated Pathway Database

Phosphorylation of SLP-76

Stable Identifier
R-HSA-202216
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Once SLP-76 is recruited to Gads its rapidly phosphorylated on the tyrosine residues in the N-terminal acidic domain. This domain contains three tyrosine phosphorylation sites, Y113, Y128 and Y145. These tyrosine residues are phosphorylated by tyrosine kinase ZAP-70 and these phosphorylated tyrosine residues provide the binding site for the SH2 domains of the incoming signaling proteins like Vav, Itk and PLC-gamma1.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
protein tyrosine kinase activity of Activated ZAP-70 [plasma membrane] Activated ZAP-70 [plasma membrane] protein tyrosine kinase activity (0004713)
Orthologous Events