Once SLP-76 is recruited to Gads its rapidly phosphorylated on the tyrosine residues in the N-terminal acidic domain. This domain contains three tyrosine phosphorylation sites, Y113, Y128 and Y145. These tyrosine residues are phosphorylated by tyrosine kinase ZAP-70 and these phosphorylated tyrosine residues provide the binding site for the SH2 domains of the incoming signaling proteins like Vav, Itk and PLC-gamma1.
|Activated ZAP-70||protein tyrosine kinase activity (0004713)|
|17652306||Keeping the (kinase) party going: SLP-76 and ITK dance to the beat||Sci STKE||2007|