Phosphorylation of PKC theta

Stable Identifier
R-HSA-202222
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Raft localized PKC theta is further phosphorylated and activated by PDK1. The threonine residue (T538) in the kinase domain is the potential target of PDK1. Phosphorylation of this site is critical for the PKC theta kinase activity, and its ability to activate NF-kB pathway. PKC theta is later trans-autophopshorylated on putative phosphorylation sites (S676, S695) for the fine-tuning of its kinase activity.

Literature References
PubMed ID Title Journal Year
12473184 Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death J Biochem (Tokyo) 2002
16978534 Selective function of PKC-theta in T cells Cell Mol Immunol 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PDK1:PIP2,PIP3 [plasma membrane]
Physical Entity
Activity
Orthologous Events