Reactome: A Curated Pathway Database

Phosphorylation of PKC theta (R-HSA-202222) [Homo sapiens]


Raft localized PKC theta is further phosphorylated and activated by PDK1. The threonine residue (T538) in the kinase domain is the potential target of PDK1. Phosphorylation of this site is critical for the PKC theta kinase activity, and its ability to activate NF-kB pathway. PKC theta is later trans-autophopshorylated on putative phosphorylation sites (S676, S695) for the fine-tuning of its kinase activity.

Additional Information
Compartment plasma membrane , cytosol
Catalyst Activity
PhysicalEntity Activity Active Units
PDK1:PIP2,PIP3 protein serine/threonine kinase activity (0004674)  
Literature References
pubMedId Title Journal Year
16978534 Selective function of PKC-theta in T cells Cell Mol Immunol 2006
12473184 Protein kinase C-theta (PKC theta): a key enzyme in T cell life and death J Biochem (Tokyo) 2002