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ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)

Stable Identifier
R-HSA-2022378
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
ACE2 Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)
Locations in the PathwayBrowser
Summation

Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002).

Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
metallocarboxypeptidase activity of ACE2(18-805) [plasma membrane]
Physical Entity
Activity
Orthologous Events