Reactome: A Curated Pathway Database

ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)

Stable Identifier
R-HSA-2022378
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
ACE2 Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)
Locations in the PathwayBrowser
Summation

Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
metallocarboxypeptidase activity of ACE2(18-805) [plasma membrane] ACE2(18-805) [plasma membrane] metallocarboxypeptidase activity (0004181)
Orthologous Events