Reactome: A Curated Pathway Database

ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)

Stable Identifier
R-HSA-2022379
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
ACE2 Hydrolyzes Angiotensin II to Yield Angiotensin-(1-7)
Locations in the PathwayBrowser
Summation

Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-8) (angiotensin II) to yield angiotensin-(1-7) (Vickers et al. 2002, Rice et al. 2004). The activity of ACE2 on angiotensin-(1-8) is 400-fold higher than on angiotensin-(1-10) (Vickers et al. 2002).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
metallocarboxypeptidase activity of ACE2(18-805) [plasma membrane] ACE2(18-805) [plasma membrane] metallocarboxypeptidase activity (0004181)
Orthologous Events