Reactome: A Curated Pathway Database

ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (R-HSA-2022379)

Species Homo sapiens


Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-8) (angiotensin II) to yield angiotensin-(1-7) (Vickers et al. 2002, Rice et al. 2004). The activity of ACE2 on angiotensin-(1-8) is 400-fold higher than on angiotensin-(1-10) (Vickers et al. 2002).

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Additional Information
Compartment extracellular region , plasma membrane
GO Biological Process angiotensin maturation (0002003)
Components of this entry
Input entries
Output entries
Catalyst Activity
PhysicalEntity Activity Active Units
ACE2(18-805) metallocarboxypeptidase activity (0004181)