Reactome: A Curated Pathway Database
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ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)

Stable Identifier
R-HSA-2022393
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
ANPEP Hydrolyzes Angiotensin III to Yield Angiotensin IV
Locations in the PathwayBrowser
Summation

Aminopeptidase N (APN, ANPEP, aminopeptidase M, alanyl aminopeptidase) hydrolyzes angiotensin-(2-8) (angiotensin III) to yield angiotensin-(3-8) (angiotensin IV) (see the positive control reactions in Diaz-Perales et al. 2005). Aminopeptidase O (AOPEP) also hydrolyzes angiotensin-(2-8) to angiotensin-(3-8) in vitro (Diaz-Perales et al. 2005) but AOPEP is located in the nucleolus in vivo (Axton et al. 2008) and angiotensin-(2-8) has not been observed in the nucleus.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
metallopeptidase activity of ANPEP Dimer [plasma membrane] ANPEP Dimer [plasma membrane] metallopeptidase activity (0008237)
Inferred From